Medical Design Briefs - July 2023 - 34

Brain Computer Interface Helps Immobilized Patients
Control Devices
The technology could be
used for spinal cord injury.
Aalto University
Espoo, Finland
A new project at Aalto University is
developing techniques that will enable
immobilized patients to control devices
using their brain activity. The project
builds on the multi-locus transcranial
magnetic stimulation (mTMS) technology
developed at Aalto, adapting it into
a brain-computer interface (BCI) that
can help patients with neurological
conditions.
" Our aim is to enable patients to control
various instruments with the power
of thought, for example by imagining
moving their arm. With personalized
technology, we could use brain measurements
to detect the intention to
move the arm nearly in real time and
apply that for motor rehabilitation, "
says Pantelis Lioumis, adjunct professor
and research fellow at Aalto University
who is leading the new project. The BCI
will combine mTMS with EEG technology
of Bittium Biosignals, a partner in
the research.
The EEG system allows real-time
data streaming, which provides brain
signals as input to the mTMS system.
The mTMS system can then stimulate
another region of the patient's brain-
thus, quite remarkably, activity in one
part of the brain can be used to stimulate
another. Because mTMS shifts the
stimulation location electronically,
specific areas can be rapidly and precisely
activated, guided by the EEG
readings.
The mTMS system, developed as part
of an international research project led
by Aalto's Prof. Risto Ilmoniemi, can
provoke limb twitches by stimulating
the motor cortex.
" A robot controlled by algorithms, instead
of a therapist, will stimulate the
brain, and it will be able to shift the
stimulation location electronically and
automatically depending on how the
brain reacts, " says Ilmoniemi. " With the
technology we've developed so far, it's
already possible to control the stimulation
based on real-time brain signals. "
34
To succeed, this project will pull together skills and expertise from many fields. Pantelis Lioumis (from left), Matilda Makkonen,
Ana Maria Soto and Tuomas Mutanen demonstrating the use of the new TMS device. (Credit: Mikko Raskinen)
n The Right Time and Place
It's vital that the correct brain area be
stimulated at the right time and in the
right place. Because electromagnetic interference
produced by TMS can be tens
of thousands of times stronger than the
EEG signals, the TMS masks the EEG
waveform.
" We need to be able to extract invisible
EEG information - in this case, a
patient's intention to move their arm.
That means we have to remove the
harmful interference in real time, " says
Jukka Kinnunen, a sales manager at Bittium
Biosignals. Lioumis explains that
work is needed to develop algorithms
capable of distinguishing between
imagining different movements produced
by different limbs. This part of
the work is done in collaboration with
Dr. Ivan Zubarev and PhD student
Matilda Makkonen.
" This is largely a development of
mathematical methods, " adds SimoPekka
Simonaho, product manager at
Bittium Biosignals.
This technology could also be used to
treat other conditions related to brain
activity, according to Lioumis. " In the future,
this approach could also be used to
www.medicaldesignbriefs.com
treat depression, where positive and negative
thoughts can also be seen as activity
in the brain, " he says.
That activity is usually located in the
prefrontal cortex, but this varies across
patients, and BCI-TMS could be used to
deliver personalized therapy. Because
depression arises from a network of interactions
between different brain parts
instead of from a single location, treating
it will also require further refinement
of mTMS to deliver more complex
stimulation patterns - something Lioumis
and Ilmoniemi's research team
are working on.
To succeed, this project will pull together
skills and expertise from many
fields, including engineering, neurobiology,
and psychology. Dr. Sabin Sathyan, a
researcher working on the project, will
spend a year at Aalto and then a year at
Bittium Biosignals. The Brain-Computer
Interface for Automated EEG-guided
Brain Stimulation project is funded by
the Finnish Research Impact Foundation.
For more information, visit www.aalto.
fi. Contact: Pantelis Lioumis, Research
Fellow, at pantelis.lioumis@aalto.fi or
Risto Ilmoniemi, Senior Advisor, at risto.
ilmoniemi@aalto.fi.
Medical Design Briefs, July 2023
http://www.aalto.fi http://www.medicaldesignbriefs.com

Medical Design Briefs - July 2023

Table of Contents for the Digital Edition of Medical Design Briefs - July 2023

Medical Design Briefs - July 2023 - Cov1A
Medical Design Briefs - July 2023 - Cov1B
Medical Design Briefs - July 2023 - Cov1
Medical Design Briefs - July 2023 - Cov2
Medical Design Briefs - July 2023 - 1
Medical Design Briefs - July 2023 - 2
Medical Design Briefs - July 2023 - 3
Medical Design Briefs - July 2023 - 4
Medical Design Briefs - July 2023 - 5
Medical Design Briefs - July 2023 - 6
Medical Design Briefs - July 2023 - 7
Medical Design Briefs - July 2023 - 8
Medical Design Briefs - July 2023 - 9
Medical Design Briefs - July 2023 - 10
Medical Design Briefs - July 2023 - 11
Medical Design Briefs - July 2023 - 12
Medical Design Briefs - July 2023 - 13
Medical Design Briefs - July 2023 - 14
Medical Design Briefs - July 2023 - 15
Medical Design Briefs - July 2023 - 16
Medical Design Briefs - July 2023 - 17
Medical Design Briefs - July 2023 - 18
Medical Design Briefs - July 2023 - 19
Medical Design Briefs - July 2023 - 20
Medical Design Briefs - July 2023 - 21
Medical Design Briefs - July 2023 - 22
Medical Design Briefs - July 2023 - 23
Medical Design Briefs - July 2023 - 24
Medical Design Briefs - July 2023 - 25
Medical Design Briefs - July 2023 - 26
Medical Design Briefs - July 2023 - 27
Medical Design Briefs - July 2023 - 28
Medical Design Briefs - July 2023 - 29
Medical Design Briefs - July 2023 - 30
Medical Design Briefs - July 2023 - 31
Medical Design Briefs - July 2023 - 32
Medical Design Briefs - July 2023 - 33
Medical Design Briefs - July 2023 - 34
Medical Design Briefs - July 2023 - 35
Medical Design Briefs - July 2023 - 36
Medical Design Briefs - July 2023 - 37
Medical Design Briefs - July 2023 - 38
Medical Design Briefs - July 2023 - 39
Medical Design Briefs - July 2023 - 40
Medical Design Briefs - July 2023 - 41
Medical Design Briefs - July 2023 - 42
Medical Design Briefs - July 2023 - Cov3
Medical Design Briefs - July 2023 - Cov4
https://www.nxtbook.com/smg/techbriefs/24MDB02
https://www.nxtbook.com/smg/techbriefs/24MDB01
https://www.nxtbook.com/smg/techbriefs/23MDB12
https://www.nxtbook.com/smg/techbriefs/23MDB11
https://www.nxtbook.com/smg/techbriefs/23MDB10
https://www.nxtbook.com/smg/techbriefs/23MDB09
https://www.nxtbook.com/smg/techbriefs/23MDB08
https://www.nxtbook.com/smg/techbriefs/23MDB07
https://www.nxtbook.com/smg/techbriefs/23MDB06
https://www.nxtbook.com/smg/techbriefs/23MDB05
https://www.nxtbook.com/smg/techbriefs/23MDB04
https://www.nxtbook.com/smg/techbriefs/23MDB03
https://www.nxtbook.com/smg/techbriefs/23MDB02
https://www.nxtbook.com/smg/techbriefs/23MDB01
https://www.nxtbook.com/smg/techbriefs/techleaders22
https://www.nxtbook.com/smg/techbriefs/22MDB12
https://www.nxtbook.com/smg/techbriefs/22MDB11
https://www.nxtbook.com/smg/techbriefs/22MDB10
https://www.nxtbook.com/smg/techbriefs/22MDB09
https://www.nxtbook.com/smg/techbriefs/22MDB08
https://www.nxtbook.com/smg/techbriefs/22MDB07
https://www.nxtbook.com/smg/techbriefs/22MDB06
https://www.nxtbook.com/smg/techbriefs/22MDB04
https://www.nxtbook.com/smg/techbriefs/techleaders21
https://www.nxtbook.com/smg/techbriefs/22MDB03
https://www.nxtbook.com/smg/techbriefs/22MDB02
https://www.nxtbook.com/smg/techbriefs/22MDB01
https://www.nxtbook.com/smg/techbriefs/21MDB12
https://www.nxtbook.com/smg/techbriefs/21MDB11
https://www.nxtbook.com/smg/techbriefs/21MDB10
https://www.nxtbook.com/smg/techbriefs/21MDB09
https://www.nxtbook.com/smg/techbriefs/21MDB08
https://www.nxtbook.com/smg/techbriefs/21MDB07
https://www.nxtbook.com/smg/techbriefs/21MDB06
https://www.nxtbook.com/smg/techbriefs/21MDB05
https://www.nxtbook.com/smg/techbriefs/21MDB04
https://www.nxtbook.com/smg/techbriefs/21MDB02
https://www.nxtbookmedia.com