Medical Design Briefs - February 2024 - 60

accuracy, on par with existing state-of-theart
methods. The device also works at
extremely low concentrations, meaning
that it needs small quantities for samples
- down to just a few microliters.
In addition, the tests showed that the
device performed well even when the
samples analyzed contained other proteins.
Tau proteins were more difficult to
detect. But because the device looks at
three different biomarkers, it can combine
results from all three to arrive at a
reliable overall result.
The technology has been licensed from
UC San Diego to a biotechnology start-up
Ampera Life. Lal is the company's chairman
but does not receive financial support
for his research from the company.
Next steps include testing blood plasma
and cerebrospinal fluid with the device,
then finally saliva and urine samples.
The tests would take place in hospital
settings and nursing homes. If those tests
go well, Ampera Life plans to apply for
FDA approval for the device, hopefully in
the next five or six months. The ultimate
goal is to have the device on the market
in a year.
Funding for the research came from the
National Institutes of Health, the University
of California San Diego and the Chinese
Academy of Sciences. In addition,
researchers used facilities that are a part of
the NSF-funded UC San Diego Materials
Research Science and Engineering Center.
This article was written by Iona Patringenaru,
UCSD. For more information,
contact Ratneshwar Lal, rlal@ucsd.edu
or visit https://jacobsschool.ucsd.edu.
Wearable Ultrasound Monitor Can Aid Rehabilitation
from Injury
The ultrasound imaging can
provide real-time insights
into muscle dynamics.
Acoustical Society of America
Melville, NY
Millions suffer from musculoskeletal
injuries every year, and the recovery
process can often be long and difficult.
Patients typically undergo rehabilitation,
slowly rebuilding muscle strength as
their injuries heal. Medical professionals
routinely evaluate a patient's progress
via a series of tasks and exercises. However,
because of the dynamic nature of
these exercises, obtaining a clear picture
of real-time muscle function is extremely
challenging.
Parag Chitnis, PhD, of George Mason
University led a team that developed a
wearable ultrasound system that can
produce clinically relevant information
about muscle function during dynamic
physical activity.
Many medical technologies can give
doctors a window into the inner workings
of a patient's body, but few can be
used while that patient is moving. A
wearable ultrasound monitor can move
with the patient and provide an unprecedented
level of insight into body
dynamics.
" For instance, when an individual is
performing a specific exercise for rehabilitation,
our devices can be used to
ensure that the target muscle is actually
being activated and used correctly, "
says Chitnis. " Other applications include
providing athletes with insights
60
A wearable ultrasound monitor can provide insight into dynamic muscle movement during activities like jumping.
(Credit: Parag Chitnis)
into their physical fitness and performance,
assessing and guiding recovery
of motor function in stroke patients,
and assessing balance and stability in elderly
populations during routine everyday
tasks. "
Designing a wearable ultrasound device
took much more than simply strapping
an existing ultrasound monitor
to a patient. Chitnis and his team reinvented
ultrasound technology nearly
from scratch to produce the results they
needed.
" We had to completely change the
paradigm of ultrasound imaging, " says
Chitnis. " Traditionally, ultrasound systems
transmit short-duration pulses, and
the echo signals are used to make clinically
usefully images. Our systems use a
www.medicaldesignbriefs.com
patented approach that relies on transmission
of long-duration chirps, which
allows us to perform ultrasound sensing
using the same components one might
find in their car radio. "
This modified approach allowed the
team to design a simpler, cheaper system
that could be miniaturized and powered
by batteries. This let them design an ultrasound
monitor with a small, portable
form factor that could be attached to a
patient.
Soon, Chitnis hopes to further improve
his device and develop software
tools to more quickly interpret and analyze
the ultrasound signals.
For more information, contact Parag
Chitnis, pchitnis@gmu.edu or visit www.
gmu.edu.
Medical Design Briefs, February 2024
https://jacobsschool.ucsd.edu http://www.gmu.edu http://www.medicaldesignbriefs.com

Medical Design Briefs - February 2024

Table of Contents for the Digital Edition of Medical Design Briefs - February 2024

Medical Design Briefs - February 2024 - Cover Flap
Medical Design Briefs - February 2024 - Cover Flap1A
Medical Design Briefs - February 2024 - Cover1
Medical Design Briefs - February 2024 - Cover2
Medical Design Briefs - February 2024 - 1
Medical Design Briefs - February 2024 - 2
Medical Design Briefs - February 2024 - 3
Medical Design Briefs - February 2024 - 4
Medical Design Briefs - February 2024 - 5
Medical Design Briefs - February 2024 - 6
Medical Design Briefs - February 2024 - 7
Medical Design Briefs - February 2024 - 8
Medical Design Briefs - February 2024 - 9
Medical Design Briefs - February 2024 - 10
Medical Design Briefs - February 2024 - 11
Medical Design Briefs - February 2024 - 12
Medical Design Briefs - February 2024 - 13
Medical Design Briefs - February 2024 - 14
Medical Design Briefs - February 2024 - 15
Medical Design Briefs - February 2024 - 16
Medical Design Briefs - February 2024 - 17
Medical Design Briefs - February 2024 - 18
Medical Design Briefs - February 2024 - 19
Medical Design Briefs - February 2024 - 20
Medical Design Briefs - February 2024 - 21
Medical Design Briefs - February 2024 - 22
Medical Design Briefs - February 2024 - 23
Medical Design Briefs - February 2024 - 24
Medical Design Briefs - February 2024 - 25
Medical Design Briefs - February 2024 - 26
Medical Design Briefs - February 2024 - 27
Medical Design Briefs - February 2024 - 28
Medical Design Briefs - February 2024 - 29
Medical Design Briefs - February 2024 - 30
Medical Design Briefs - February 2024 - 31
Medical Design Briefs - February 2024 - 32
Medical Design Briefs - February 2024 - 33
Medical Design Briefs - February 2024 - 34
Medical Design Briefs - February 2024 - 35
Medical Design Briefs - February 2024 - 36
Medical Design Briefs - February 2024 - 37
Medical Design Briefs - February 2024 - 38
Medical Design Briefs - February 2024 - 39
Medical Design Briefs - February 2024 - 40
Medical Design Briefs - February 2024 - 41
Medical Design Briefs - February 2024 - 42
Medical Design Briefs - February 2024 - 43
Medical Design Briefs - February 2024 - 44
Medical Design Briefs - February 2024 - 45
Medical Design Briefs - February 2024 - 46
Medical Design Briefs - February 2024 - 47
Medical Design Briefs - February 2024 - 48
Medical Design Briefs - February 2024 - 49
Medical Design Briefs - February 2024 - 50
Medical Design Briefs - February 2024 - 51
Medical Design Briefs - February 2024 - 52
Medical Design Briefs - February 2024 - 53
Medical Design Briefs - February 2024 - 54
Medical Design Briefs - February 2024 - 55
Medical Design Briefs - February 2024 - 56
Medical Design Briefs - February 2024 - 57
Medical Design Briefs - February 2024 - 58
Medical Design Briefs - February 2024 - 59
Medical Design Briefs - February 2024 - 60
Medical Design Briefs - February 2024 - 61
Medical Design Briefs - February 2024 - 62
Medical Design Briefs - February 2024 - 63
Medical Design Briefs - February 2024 - 64
Medical Design Briefs - February 2024 - 65
Medical Design Briefs - February 2024 - 66
Medical Design Briefs - February 2024 - Cover3
Medical Design Briefs - February 2024 - Cover4
https://www.nxtbook.com/smg/techbriefs/24MDB05
https://www.nxtbook.com/smg/techbriefs/24MDB04
https://www.nxtbook.com/smg/techbriefs/24MDB03
https://www.nxtbook.com/smg/techbriefs/24MDB02
https://www.nxtbook.com/smg/techbriefs/24MDB01
https://www.nxtbook.com/smg/techbriefs/23MDB12
https://www.nxtbook.com/smg/techbriefs/23MDB11
https://www.nxtbook.com/smg/techbriefs/23MDB10
https://www.nxtbook.com/smg/techbriefs/23MDB09
https://www.nxtbook.com/smg/techbriefs/23MDB08
https://www.nxtbook.com/smg/techbriefs/23MDB07
https://www.nxtbook.com/smg/techbriefs/23MDB06
https://www.nxtbook.com/smg/techbriefs/23MDB05
https://www.nxtbook.com/smg/techbriefs/23MDB04
https://www.nxtbook.com/smg/techbriefs/23MDB03
https://www.nxtbook.com/smg/techbriefs/23MDB02
https://www.nxtbook.com/smg/techbriefs/23MDB01
https://www.nxtbook.com/smg/techbriefs/techleaders22
https://www.nxtbook.com/smg/techbriefs/22MDB12
https://www.nxtbook.com/smg/techbriefs/22MDB11
https://www.nxtbook.com/smg/techbriefs/22MDB10
https://www.nxtbook.com/smg/techbriefs/22MDB09
https://www.nxtbook.com/smg/techbriefs/22MDB08
https://www.nxtbook.com/smg/techbriefs/22MDB07
https://www.nxtbook.com/smg/techbriefs/22MDB06
https://www.nxtbook.com/smg/techbriefs/22MDB04
https://www.nxtbook.com/smg/techbriefs/techleaders21
https://www.nxtbook.com/smg/techbriefs/22MDB03
https://www.nxtbook.com/smg/techbriefs/22MDB02
https://www.nxtbook.com/smg/techbriefs/22MDB01
https://www.nxtbook.com/smg/techbriefs/21MDB12
https://www.nxtbook.com/smg/techbriefs/21MDB11
https://www.nxtbook.com/smg/techbriefs/21MDB10
https://www.nxtbook.com/smg/techbriefs/21MDB09
https://www.nxtbook.com/smg/techbriefs/21MDB08
https://www.nxtbook.com/smg/techbriefs/21MDB07
https://www.nxtbook.com/smg/techbriefs/21MDB06
https://www.nxtbook.com/smg/techbriefs/21MDB05
https://www.nxtbook.com/smg/techbriefs/21MDB04
https://www.nxtbook.com/smg/techbriefs/21MDB02
https://www.nxtbookmedia.com