Medical Design Briefs - August 2024 - 18

Advanced Drug-Delivery Systems
MDB: What new routes of administration for biologics are being
explored with the advent of high-dose formulations, and how
might these routes improve patient outcomes and experiences?
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18
Sørensen: The most essential improvement is the possible
shift from IV to subcutaneous administration, which will improve
the quality of life for the patients and likely also improve
the patient's adherence to the therapy. It is a very significant improvement
for the patient if it is possible to self-inject a subcutaneous
injection at home instead of having to visit a hospital or
infusion clinic for lengthy IV administration. The risk of an adverse
event is typically also reduced with a subcutaneous injection
versus an IV infusion.
MDB: What specific design features of reusable drug-delivery
devices for high-dose biologics have been shown to significantly
improve patient comfort and adherence to treatment protocols?
Sørensen: New possibilities include a reusable electronic
injection device that can have a completely controlled plunger
movement with the ability of very high plunger forces and
can also offer the flexibility to handle different primary packaging
systems and injection volumes. These are design features
that can offer a unique possibility for the pharmaceutical
formulation department to select the optimum formulation
parameters and still have a device option that can handle the
administration diligently due to the superior performance
envelope. From the patient perspective, the experience will
be very similar to the typical two-step autoinjector experience
and convey a very controlled and convincing experience for
the patient in a home setting.
Summary
Innovative reusable drug-delivery devices are transforming
the administration of high-dose biologics by enabling selfadministration
of challenging drug formulations. These devices
support high viscosity and larger injection volumes, enhancing
patient comfort and adherence. The shift from IV
treatments in clinical settings to subcutaneous injections at
home offers significant cost savings and improves patient quality
of life.
High-dose formulations can reduce the frequency of administration,
providing long-acting therapeutic benefits and further
reducing healthcare costs. New routes of administration,
primarily SC injections, improve patient outcomes and adherence
by minimizing the need for hospital visits and reducing
the risk of adverse events. The design features of these devices
such as controlled plunger movement significantly enhance
the patient experience, making self-administration more manageable
and reliable.
This article was written by Sherrie Trigg, Editor and Director
of Medical Content, sherrie.trigg@saemediagroup.com.
Bjarne Sørensen is Director of Front-End Innovation for Phillips
Medisize. Based in the company's Development Center in
Denmark, he has more than 35 years of experience within
product, strategy, and business development. At Phillips Medisize,
he participates in customer programs, typically involving
electronic injectors and connected health systems. For more
information, e-mail bjarne.sorensen@phillipsmedisize.com or
visit www.phillipsmedisize.com.
www.medicaldesignbriefs.com
10/20/23 1:03 PM
Medical Design Briefs, August 2024
http://info.hotims.com/86258-782 http://www.techbriefs.com/webinar414 http://www.phillipsmedisize.com https://www.medicaldesignbriefs.com
Medical Design Briefs - August 2024

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