Medical Design Briefs - August 2024 - 4
Videos of the Month
Drug-Loaded 3D Printed Films
Drug-loaded 3D printed films could change cancer treatments
forever as world first research from the University of South
Australia shows the new films kill liver cancer cells by more than
80 percent, with less systematic toxicities of chemotherapy.
Created from gels, the biodegradable 3D printed films are loaded
with tailored doses of anti-cancer drugs 5-fluorouracil (5FU) and
cisplatin (Cis) and placed at the exact surgical site where a cancer
has been removed, localizing drugs to the affected area while
limiting the undesirable side effects of traditional chemotherapy.
Discovery Boosts Potential of New Cancer-Fighting
Drugs
Scientists at Scripps Research have uncovered a critical
feature that a promising new class of cancer drugs, known as
CELMoDs, needs to be effective. CELMoDs are designed to
attack cancer in a novel way, by binding to a regulatory protein
called cereblon, which then triggers the degradation of key
cancer-driving proteins.
The Bridge Recombination Mechanism - Next
Generation Genome Design
Researchers have discovered the bridge recombinase
mechanism, a precise and powerful tool to recombine and
rearrange DNA in a programmable way. Going far beyond
programmable genetic scissors like CRISPR, the bridge
recombinase mechanism enables scientists to specify not only
the target DNA to be modified, but also the donor material to be
recognized, so they can insert new, functional genetic material,
cut out faulty DNA, or invert any two sequences of interest.
Immunotherapy: Drug Harnesses Immune System
Against Cancer
Certain types of immune cells called regulatory T-cells, while
vital for a balanced immune system, can hinder the cancerkilling
process. Targeting these cells without affecting other
immune cells in the past has been difficult. A new drug can stop
regulatory T-cells from working while leaving other immune cells
intact to fight the cancer cells. Watch this drug in action in this
short animation.
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Medical Design Briefs, August 2024
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Medical Design Briefs - August 2024
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