Milling & Baking News - September 8, 2020 - 28

Milling Technology

Calyxt foresees a decade of
gene-editing innovation in crops
ROSEVILLE, MINN. - Calyxt, Inc.
achieved a milestone in 2019 when higholeic soybeans became the company's
first commercially available gene-edited
product in the United States through the
company's TALEN technology. More
milestones may come in other crops
throughout the current decade. Projects
in the pipeline include high-fiber wheat,
hemp with a more marketable yield,
cold-tolerant oat crops and pulses with
improved protein profiles and flavor.
"We are really, really excited at Calyxt
about the unlimited possibilities that exist
with plant-based foods and what we might
be able to do to help bring some of these innovations to consumers," said Travis Frey,
PhD, chief technology officer, in an Aug.
19 webinar hosted by Food Business News, a
sister publication of Milling & Baking News.
Research at the University of Minnesota
created TALEN. Dan Voytas, PhD, a professor in the College of Biological Sciences
at the university, is now Calyxt's chief
science officer. The TALEN technology
makes precise alternations to the genetic
code of plants. Dr. Voytas said the TALEN
technology is similar to what farmers and
plant breeders have done for centuries.
"Our gene-editing methods, however,
are much faster and more precise than
traditional breeding approaches," Dr.
Voytas said. "This allows us to make new
products faster in a fraction of the time

and a fraction of the cost."
Products created through TALEN technology do not have to be labeled as bioengineered under US Department of Agriculture regulations, said Chloe Pavely,
global regulatory director for Calyxt. The
products are not GMO, she said.
"The products we develop are different in two essential aspects," she said.
"First, they contain no foreign DNA, and

CALYXT

second, they could be obtained through
conventional breeding. It would just take
a lot longer, probably decades."
CRISPR is another gene-editing technology. Australia has granted Calyxt a
patent covering CRISPR gene editing in
plants, Dr. Voytas said.
Roseville-based Calyxt has three go-tomarket strategies. One involves licensing
the TALEN technology to companies for
use in their own development of specific

KSU seeks to improve wheat
through gene-editing technology
MANHATTAN, KAN. - Kansas State
University (KSU) and the University of
Saskatchewan are teaming up to improve
wheat using genome-editing technology.
Groups will cooperate on a $650,000
grant from the US Department of Agriculture's National Institute of Food and
Agriculture (NIFA).
KSU's work on the project will be led
by Eduard Akhunov, PhD, a wheat geneticist. He will work with Harold Trick,
a professor in KSU's Department of Plant
Pathology, and his research team. Both
will join researchers at the University of
Saskatchewan in using genome editing
technology to improve productivity and
nutrition in the world's wheat lines.
Dr. Akhunov said the genome editing
is based on technology called "clustered
regularly interspaced short palindromic
repeats," also referred to as CRISPR.
"CRISPR is a powerful and extremely
28 / September 8, 2020

Milling & Baking News

precise molecular tool capable of making targeted changes in genetic code," Dr.
Akhunov said. "It allows us to produce
novel variants of genes that have improved properties and create a positive
impact on the traits of interest."
Use of the CRISPR technology will allow researchers to zero in on positive or
valuable traits that can accelerate the development of crops that produce higher
yields, quality and nutrition.
"Our project will use the capabilities
of CRISPR-Cas (referring to use of the
technology with an associated protein)
to empower traditional breeding strategies," Dr. Akhunov said. "Integrating
this tool into modern breeding practices
can substantially speed up the rate of
genetic gain by accelerating the identification of agronomic genes, broadening
genetic diversity and reducing the time
required for traits introgression (trans-

traits. Another strategy involves Calyxt
licensing the company's developed traits
or products to downstream partners with
commercial expertise for negotiated upfront and milestone payments and potential royalties. In the third strategy, Calyxt
will sell seeds to agricultural processors,
including millers and crushers, or others
in the relevant crop's supply chain.
"We are really, really interested in collaboration," Dr. Frey said.
Calyxt was founded in 2010, and an
initial public offering occurred in 2017.
Company stock trades on the Nasdaq.
High-oleic soybean oil containing about
80% oleic acid and up to 20% less saturated fat launched commercially in February 2019. The oil has up to three times the
fry life and extended shelf life compared
to commodity oils, according to Calyxt.
High-oleic, low-linolenic (HOLL) soybeans may launch as early as 2023.
Calyxt is collaborating with S&W Seed
Co., Longmont, Colo., on enhanced traits
in alfalfa that have been shown to improve productivity, decrease input costs
and improve digestibility in livestock fed
the alfalfa.
Calyxt has targeted 2022 as the commercial planting year for high-fiber wheat,
2023 as the commercial planting year for
hemp with marketable yield and 2026 as
the commercial planting year for coldtolerant oat crops. Dr. Frey said the oats
could be a winter crop in crop rotation
plans. Calyxt has targeted 2027 as the commercial planting year for pulses with improved protein profiles and flavor. MBN
fer) into the adapted germplasm."
The University of Saskatchewan's research will be led by Curtis Pozniak, director of the Crop Development Centre at
the University of Saskatchewan.
The goal of the partnership is to use
CRISPR technology to introduce domesticated traits into wild wheat relatives.
"These efforts may pave new ways
for broadening the genetic diversity of
modern bread wheat by creating newly
domesticated varieties of wild crops,"
Dr. Akhunov said. "Our combined
efforts should help to establish the
CRISPR-Cas technology as a precision
breeding tool in the wheat breeder's
toolbox for characterizing, developing
and transferring traits into their breeding programs."
The project will collaborate closely
with NIFA's Wheat Coordinated Agriculture Project (Wheat-CAP), a multi-state
project; the International Wheat Yield
Partnership; and the NIFA IWYP Winter
Wheat Breeding Innovation Hub, which
was recently established at KSU. MBN
bakingbusiness.com / world-grain.com


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Milling & Baking News - September 8, 2020

Table of Contents for the Digital Edition of Milling & Baking News - September 8, 2020

Milling & Baking News - September 8, 2020 - 1
Milling & Baking News - September 8, 2020 - 1
Milling & Baking News - September 8, 2020 - 2
Milling & Baking News - September 8, 2020 - 3
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Milling & Baking News - September 8, 2020 - 42
Milling & Baking News - September 8, 2020 - 43
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Milling & Baking News - September 8, 2020 - 48
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Milling & Baking News - September 8, 2020 - 56
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