SABCS 2021 Meeting News Preview - 4

4
PREVIEW EDITION | SABCSMEETINGNEWS.ORG
Debate will tackle 1-week versus 3-week whole breast
radiation for early-stage breast cancer
I
n April 2020, at the height of the first
wave of the COVID-19 pandemic, the
5-year efficacy results of the FAST-Forward
trial were published showing that 1
week of whole breast radiotherapy was
noninferior to the standard schedule given
over 3 weeks for women with early-stage
breast cancer after primary surgery.
The study compared 40 Gy in 15
fractions over 3 weeks, 27 Gy in five
fractions over 1 week, and 26 Gy in five
fractions over 1 week to the whole breast
(>93% of cases) or chest wall. The 26 Gy
in five fractions over 1 week regimen was
noninferior to the standard and was safe
in terms of normal tissue effects up to 5
years. Interestingly, patient and photographic
assessments suggested worse
normal tissue effects for 27 Gy compared
to 40 Gy, but not for 26 Gy compared to
40 Gy.
" This regimen of 26 Gy in 1 week looks
to be equivalent and more convenient
for patients, " according to Wendy Woodward,
MD, PhD, of University of Texas M.D.
Anderson Cancer Center, Houston, Texas.
" The question then becomes: Should we
adopt this universally now or wait for more
data including longer follow-up? "
An SABCS 2021 debate, One Week of
Whole Breast RT is the New Standard of
Care, will address that question. Dr. Woodward
will moderate the debate, which is
currently scheduled for Thursday, Dec. 9.
Charlotte Coles, MBChB,
D
PhD, Professor of
Breast Cancer
Clinical Oncology
and Deputy
Head of Department
of
Oncology
at the University
of
Cambridge
in the UK,
will present
the " Pro "
argument,
and Julia
White, MD,
Professor and Vice
Chair Clinical Research
at the Stefanie Spielman
Comprehensive Breast Center at Ohio
State University, will present the " Con "
argument.
According to Dr. Woodward, it used to
be that all early-stage breast cancer treated
with lumpectomy would be followed
with 5 or 6 weeks of radiation to the whole
breast. Years ago, studies done in Canada
and the United Kingdom developed and
tested a 3-week radiation schedule that
delivered an equivalent dose.
" The one challenge that gives people
a little bit of pause is that a bigger
radiation dose per fraction
carries more risk for late toxicity, "
Dr. Woodward said.
However, the studies
of the 3-week regimen
had 10 years of
said. " There are compelling arguments
on the other side as well. "
This debate has received even greater
R
attention in the time of the COVID-19
pandemic.
" We want to reduce the time people
spend in facilities without compromising
care, " Dr. Woodward said. " I think that
may have pushed people to move to this
schedule sooner than we might have in
normal times. "
WE WANT TO REDUCE THE TIME
PEOPLE SPEND IN FACILITIES WITHOUT
COMPROMISING CARE. I THINK THAT
MAY HAVE PUSHED PEOPLE TO MOVE
TO THIS SCHEDULE SOONER THAN WE
MIGHT HAVE IN NORMAL TIMES. "
data showing the efficacy of the schedule
with no increase in late recurrence of
cosmetic toxicities.
" Now there are some who think we
should adopt this 1-week schedule immediately
and that it is harsh to tell patients
that we have to have another trial
of the 1-week schedule or wait 10 years
before adopting this, " Dr. Woodward
Dr. Woodward hopes that, after
listening to the debate, participants
will be able to appreciate some of the
nuances of the discussion.
" It is not as simple as saying 1 week
is just as good, " she said. " For many, it
may be reasonable to choose 1 week,
but we want to help our patients make
educated decisions. " ■
Early-career scientists: Reserve your spot
for this year's Career Roundtables
THE CAREER ROUNDTABLES
provide interactive informational
interviews with experts on a variety
of topics that are important for
career development of early-career
scientists. The session is open to
early-career scientists-defined as
graduate students, postdoctoral or
clinical fellows, or medical students
and residents-who are registered
attendees of the 2021 SABCS.
Limited to 120 participants; attendance
will be on a first-come, firstserved
basis and with no pre-registration
required. Badges are required and
will be scanned at door for registration.
Boxed lunches will be provided.
Each table will feature three mentors,
two research experts and one
patient advocate, who will be available
to answer participant questions
and provide real-world advice on
the table topic. Attendees may visit
as many or few tables during the
session as they like. Some tables'
topics will have a more clinical focus,
while others will have a more laboratory
research focus. The subthemes
are denoted in parentheses after the
table topic name.
Download the
SABCS Mobile App
Maximize your Symposium experience by
downloading the 2021 SABCS Mobile App,
available for free for both Apple and Android
devices. Use the SABCS Mobile App to plan
your schedule and set up your daily itinerary
prior to the start of the Symposium and use it
during the Symposium to navigate the program
and connect with friends and colleagues.
WITH THE SABCS MOBILE APP, YOU CAN:
* Stay organized with up-to-the-minute
Exhibitor, Speaker, and Event information
WEDNESDAY, DECEMBER 8
Schedule
12:00 pm - 12:05 pm Introduction
12:05 pm - 1:00 pm
Roundtable Topics
1. Balancing Research and Clinical
Practice (Clinical)
2. How to Engage Clinicians in Your
Research (Laboratory)
3. Becoming a Successful Clinical
Trialist (Clinical), Table 1
4. Becoming a Successful Clinical
Trialist (Clinical), Table 2
5. Careers in Industry I
6. Careers in Industry II
7. Careers in Translational Research
(Clinical)
8. Careers in Translational Research
(Laboratory)
9. Funding Your Own Research
10. Making the Transition from
Fellowship to Faculty (Clinical)
11. Making the Transition from
Fellowship to Faculty (Laboratory)
12. Negotiating a Job Offer or
Promotion
13. How to Get Involved In & Make
Collaborative Research Work for
You
14. Time Management to Optimize
Productivity
15. How to Succeed as an
Underrepresented Individual in
Research
16. Professional Fulfillment and
Burnout Mitigation
The Career Development Forum is sponsored by Eisai, Inc.
SABCS Meeting News is published by TriStar Event Media,
LLC, as a service to attendees and followers of the
San Antonio Breast Cancer Symposium.
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Rotation through roundtables (at leisure)
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bookmark exhibitors
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and presentations
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colleagues through Friends
* Stay in-the-know and join in on social
media with #SABCS21
Download the SABCS Mobile App now to get
the most from your SABCS experience!
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