UEG Week Virtual 2020 Congress Review - 20

UEG Week Congress Review

UEG Research Prize

Journal Best Paper Award

Stefan Schreiber

Andrew Wisniewski

Stefan Schreiber was awarded the
distinguished UEG Research Prize for
his outstanding project; "Therapeutic
mechanisms of controlled-ileocolonicrelease nicotinamide (CICR-NAM) in IBD"

This year's UEG Journal Best Paper Award was presented
to Andrew Wisniewski, as the first author of the winning
article: 'Increased incidence of systemic serious viral
infections in patients with inflammatory bowel disease
associates with active disease and use of thiopurines'.
Andrew Wisniewski is a gastroenterologist at the Hôpital
Charles-Lemoyne of the University of Sherbrooke,
Quebec, Canada and completed an IBD Fellowship at
Sorbonne University, France.
recommendations for systemic
SVI prevention. Encouraging
timely treat-to-target practice to
decrease the burden of systemic
inflammation is key to curtailing
systemic SVI. This can safely be
achieved by carefully selecting
immunosuppressive therapy. 

"What inspired me to begin this research project was
the firm belief that molecular nutrition interventions
hold large scientific promise. Our body has known
these molecular entities for a long time and therefore
side effects can be anticipated. The key is to bring a
well-known molecule in a highly unusual concentration
to unusual places.  
We found some years ago that tryptophan degraded
during chronic inflammation, probably representing
an old evolutionary principle to curb availability of this
amino acid, to shorten invading pathogenic bacteria.
Most interestingly tryptophan starvation starts a loop in
which inflammation further amplifies, something that
can be observed in IBD in humans.
Key findings from our research identified that high dose
Nicotinamide represents a strong anti-inflammatory
principle in animal models of IBD. We could show
that this anti-inflammation principle is transferred by
microbiome changes. The anti-inflammation needs
an ileocecal release which we created and that places
Nicotinamide directly into the colon.
We are currently at a critical point in proving
the mechanism of action and clinical efficacy in
humans. This will significantly contribute to better
understanding the therapeutic mechanisms of
CICR-NAM in IBD. At present, we are in a completely
government funded system and all results will belong
to the university.
Being recognised for the work we are doing is a real
achievement and it will hopefully result in some broad
enthusiasm about molecular nutrition interventions in
chronic diseases. This is even more important because
such interventions will be cost-effective and may help
in all regions of the world where IBD is emerging, but
where financial constrains limit access to patients."
Watch the Research Prize Session
20

"Serious infections increase the
disease burden, particularly
in presence of active IBD
and prolonged exposure to
immunosuppressive agents.
However, knowledge about serious
viral infections was limited in the
lead up to the COVID-19 pandemic. 
Our research aimed to address
this knowledge gap and focused
on determining the magnitude
and drivers of systemic serious
viral infections (SVI) in the IBD
population. We queried the IBD
database MICISTA (Hopital SaintAntoine, Paris, France) over a nineyear period as well as the national
French hospital database.
We found that systemic SVI was
three-fold higher in our cohort
compared with the general
population, but the resulting
individual absolute risks remained
reassuringly low, with the
incidence rate of systemic SVI in
patients with IBD being only 2/1000
person-years. Our study also
identified active IBD and use of
thiopurines as nearly four-fold risk
factors of systemic SVI.
The significance of our findings
may be useful in shaping

In wake of the COVID-19 pandemic,
preliminary results suggest
limited rates of infection in the
IBD population. Further studies
are needed to determine risk
factors of disease activity and
immunosuppressive therapies
particular to COVID-19. Studying
newer biological agents may
further refine our clinical practice.
As new findings underscore the
importance of tumour necrosis
factor (TNF) in the "cytokine storm"
defining severe forms of COVID-19,
questions arise about the potential
role of anti-TNF therapy in treating
life-threatening COVID-19 cases."
I am deeply honoured and grateful
to the selection committee and the
UEG community for this award. I
accept this award on behalf of my
co-author Julien Kirchgesner and
our exceptional research team. I'm
deeply indebted to Jacques Cosnes
and Laurent Beaugerie for this
opportunity and their generosity in
guiding this project to completion.
On the path of discovery, I
learned the fundamentals of
research, the joy in teamwork and
received priceless mentoring in
the publication of my first major
article. Thank you."
Watch the laudation of UEG
Journal Best Paper Awardee 2020


http://www.youtube.com/watch?v=jWbyTMgLCBo https://ueg.meta-dcr.com/week2020/crs/ueg-research-prize-2020-therapeutic-mechanisms-of-controlled-ileocolonic-release-nicotinamide-cicr-nam-in-ibd

UEG Week Virtual 2020 Congress Review

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