UEG Week Virtual 2021 Congress Review - 6

UEG Week Congress Review
Scientific Programme Highlights
Endoscopic pyloromyotomy effective in refractory gastroparesis
Gastric per-oral endoscopic myotomy (G-POEM) significantly improves symptoms in patients with severe
and refractory gastroparesis, according to the results of a randomised, sham-controlled study conducted
in Slovakia and the Czech Republic. The study enrolled 41 adults with a Gastroparesis Cardinal Symptom
Index (GCSI) total score >2.3 and scintigraphy-confirmed delayed gastric emptying (GES >60%/2 hours or
10%/4 hours). Patients were randomised to undergo G-POEM or a sham procedure consisting of general
anaesthesia and upper GI endoscopy and were followed for 6 months. Sham patients with persisting
symptoms at this timepoint were offered G-POEM and followed for a further 6 months.
Of the 39 randomised patients (20 G-POEM, 19 sham) with
successful procedures who completed the 6-month follow-up, 14
(70%; 95% confidence interval [CI]: 48-85) in the G-POEM group
and three (16%; 95% CI: 6-38) in the sham group had experienced
a ≥50% reduction in GCSI from baseline (p=0.0011), which was
defined as treatment success. After G-POEM, the mean GCSI score
improved significantly from 3.48 ± 0.58 at baseline to 1.18 ± 0.87
at 6 months (p<0.001) compared with an improvement from 3.23
± 0.65 to 2.59 ± 1.05 (p=0.015) after the sham procedure (p<0.001
for G-POEM vs. sham). Median gastric retention at 4 hours, which
was assessed after 3 months of follow-up, had decreased from
21.9% (interquartile range [IQR]: 16.7-32.0) to 6.7% (IQR: 0-20.9)
after G-POEM (p=0.002), but had not changed significantly after
the sham procedure: from 26.3% (IQR: 16.4-42.2) at baseline
6
to 20.5% (IQR: 9.8-37.3) after the procedure (p=0.376). The
difference in gastric emptying improvement between G-POEM
and the sham procedure was not significant (p=0.137).
Eleven sham-treated patients subsequently received G-POEM and
completed 6 months of follow-up. Of these, nine (82%; 95% CI:
52-95) achieved treatment success at 6 months. At the 3-month
assessment, median gastric retention at 4 hours had decreased
from 26.3% (IQR: 16.4-42.2) at baseline to 3.8% (IQR: 0.3-7.9)
(p=0.022) after G-POEM.
All procedures were well tolerated with no severe perioperative
or early postoperative adverse events reported. One patient in
the G-POEM group developed severe dumping syndrome that
required drug treatment.
https://www.ueg.eu/library/endoscopic-pyloromyotomy-g-poem-improves-symptoms-in-patients-with-refractory-gastroparesis-a-randomized-sham-controlled-trial/247766

UEG Week Virtual 2021 Congress Review

Table of Contents for the Digital Edition of UEG Week Virtual 2021 Congress Review

UEG Week Virtual 2021 Congress Review - 1
UEG Week Virtual 2021 Congress Review - 2
UEG Week Virtual 2021 Congress Review - 3
UEG Week Virtual 2021 Congress Review - 4
UEG Week Virtual 2021 Congress Review - 5
UEG Week Virtual 2021 Congress Review - 6
UEG Week Virtual 2021 Congress Review - 7
UEG Week Virtual 2021 Congress Review - 8
UEG Week Virtual 2021 Congress Review - 9
UEG Week Virtual 2021 Congress Review - 10
UEG Week Virtual 2021 Congress Review - 11
UEG Week Virtual 2021 Congress Review - 12
UEG Week Virtual 2021 Congress Review - 13
UEG Week Virtual 2021 Congress Review - 14
UEG Week Virtual 2021 Congress Review - 15
UEG Week Virtual 2021 Congress Review - 16
UEG Week Virtual 2021 Congress Review - 17
UEG Week Virtual 2021 Congress Review - 18
UEG Week Virtual 2021 Congress Review - 19
UEG Week Virtual 2021 Congress Review - 20
UEG Week Virtual 2021 Congress Review - 21
UEG Week Virtual 2021 Congress Review - 22
UEG Week Virtual 2021 Congress Review - 23
UEG Week Virtual 2021 Congress Review - 24
UEG Week Virtual 2021 Congress Review - 25
UEG Week Virtual 2021 Congress Review - 26
UEG Week Virtual 2021 Congress Review - 27
UEG Week Virtual 2021 Congress Review - 28
https://www.nxtbookmedia.com