WhiteBook2_Part2 - 18

Results
The number of academic journal publications by digestive disorder is shown in Figure 11.
Among the digestive neoplasms, colon and rectum (148,401) and liver (113,060) neoplasms
had a large number of publications, compared to oesophageal (34,772) and gallbladder and
biliary tract (19,242) neoplasms. Among the digestive diseases analysed, inflammatory bowel
disease (56,027) had a large number of publications, whereas dyspepsia and eosinophilic
oesophagitis each had <5000 publications. Only the chronic liver disease sub-categories are
shown in Figure 11, and chronic liver diseases overall had 123,125 related publications.
Figure 11.
Number of academic journal publications by digestive disorder
150,000
100,000
50,000
Source: authors' compilation using data extracted from MEDLINE database.
Publications limited to human studies , published since the year 2000. Publications may be assigned to more than one disorder .
Figure 12 and Figure 13 show the relationship between the number of digestive disorder
related academic journal publications and the global number of DALYs per disorder in 2019
(for which data were available). Stomach and oesophageal neoplasms appeared to be underresearched
in relation to global disease burden compared to the other digestive neoplasms.
Amongst the digestive diseases, alcohol-related liver disease had few publications compared
to a relatively high level of burden. Inflammatory bowel disease, on the other hand, had
almost 50,000 additional publications compared to alcohol-related liver disease, but over 9
million fewer DALYs.
Higher income countries tend to produce more research publications and may have different
research priorities compared to lower income countries, however, the main findings in
relation to inflammatory bowel disease and alcohol-related liver disease were observed when
comparing global publication output with disease burden in the EU (see Appendix).
White Book 2: Part 2
15
Colon and rectum neoplasms
Liver neoplasms
Stomach neoplasms
Pancreatic neoplasms
Oesophageal neoplasms
Gallbladder and biliary tract neoplasms
Inflammatory bowel disease
Gallbladder and biliary diseases
Chronic hepatitis C
Pancreatitis
Paralytic ileus and intestinal obstruction
Gastroesophageal reflux disease
Chronic hepatitis B
Non−alcoholic fatty liver disease
Coeliac disease
Peptic ulcer disease
Inguinal, femoral, and abdominal hernia
Appendicitis
Gastritis and duodenitis
Irritable bowel syndrome
Alcohol−related liver disease
Dyspepsia
Eosinophilic oesophagitis
Number of publications

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