Clinical OMICs - Issue 3 - (Page 22)

(continued from previous page) metabolites, organ-specific blood proteins for the brain, heart, and liver (measure general wellness to disease transitions), white blood cell epigenetics, and salivary cortisol levels (stress) four times a year. We are working on new assays to assess more effectively immune responses and inflammation-signal features of many different diseases. It is important that rigorous standards be created both for sample procurement and for assessing each of the individual data types so that the data can be integrated successfully and mined for discovery. We also believe that these data must be shared freely among the groups that are working together to accelerate progress for the patients who need the healthcare advances. These data for each individual will be aggregated, integrated, mined, and models created to help prioritize the actionable opportunities for each individual. Developing the analytics will be one of the largest challenges of this study. Actionable Possibilities and Coaching An actionable possibility is a feature for an individual that, if corrected, could improve wellness or avoid disease. Let me give two examples. A friend was told that he had early onset osteoporosis in his mid-30s-a disease that potentially could confine him to a wheelchair for the rest of his life. After genetic analysis, he discov- 22 Clinical OMICs May 15, 2014 The Institute for Systems Biology has presented an overview of the Hundred Person Wellness Project. ered that he had a defective calcium transporter. He took 20 times the normal amount of calcium for several years and returned his bone structure to normal. After about 12 years he continues to remain normal on this regimen. Thus this genetic defect is actionable in that it can be corrected by a vitamin. A second example was a physicist who began to lose interest in his work and had difficulty concentrating and finding the same joy in his life and work as he had previously. After this continued for a considerable time, he began to question whether he should completely change his life trajectory. Upon undergoing blood screening, it turned out that he was strikingly deficient in iron. Within days after replacement therapy he returned to normal and resumed his former life with his typical enthusiasm. In this case the defect was an environmental deficiency that could readily be corrected. We believe the genome has 300500 actionable genetic variants and many of them lead to nutritional deficiencies. Hence our feeling is that every individual will have multiple actionable possibilities that can be corrected. An important point is that new actionable possibilities will be revealed as we integrate together different combinations of data. We plan to have coaches that can take these actionable possibilities and explain them to the individuals, hopefully, in such a manner that the individuals will be moved to act upon their actionable possibilities. Of course, physician oversight and treat- www.clinicalomics.com http://www.clinicalomics.com

Table of Contents for the Digital Edition of Clinical OMICs - Issue 3

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Clinical OMICs - Issue 3