APR March 2021 - 71

SECTION TITLE

Gastro-Retentive Dosage Forms for
Sustained Drug Delivery;

Devices and Methods for
Controlling Tremor;

The present patent relates to floating gastro-retentive oral dosage forms
for modified release of active pharmaceutical agents. Gastro-retentive
oral dosage forms are particularly beneficial for drugs having a narrow
absorption window (NAW) in the upper gastrointestinal (GI) tract. Weakly
basic drugs that have high pH-dependent solubility, drugs that act locally
in the upper GI tract, drugs that degrade in the colon, or drugs that disturb
normal colonic microbes are good candidates for such a technology. The
rapidly expanding floating gastro-retentive dosage forms feature a matrix
core. This sustained release swellable matrix core comprises an active
agent, a super-disintegrant, a water-soluble polymer, an acid, and a gasgenerating agent; and a membrane that is a water-insoluble, permeable,
elastic, and self-adjusting comprising a plasticizer and at least one
copolymer. The membrane surrounds the matrix core. The floating gastroretentive dosage form provides sustained release of the active agent in
a patient's stomach and swells to approximately 200% in gastric fluid in
about 30 minutes. The patent also provides rapidly expanding sustained
release or combined immediate release and sustained release formulations
that require targeted release in the proximal gastro-intestinal tract.

A tremor is a rhythmic shaking movement in one or more
parts of your body. It is involuntary. There are various types
of tremors like Essential Tremor (ET), Parkinsonian Tremor
and Dystonic Tremors. ET is the most common type.
It usually affects your hands, but it can also affect your
head, voice, tongue, legs, and trunk. There is no cure for
most forms of tremor, but there are treatments available
like drugs and brain surgery to help manage symptoms.
But there is a great need for alternative treatments for
ET patients that reduce tremors without the side effects
of drugs and without the risks of brain surgery. Present
patent relates to system, devices, and methods for
treating tremor by stimulation of a peripheral nerve. A
peripheral nerve stimulator can be used to stimulate a
peripheral nerve to treat ET, Parkinson Tremor, and other
forms of tremor. The peripheral nerve stimulator can be
either a non-invasive surface stimulator or an implanted
stimulator. Stimulation can be electrical, mechanical, or
chemical. Stimulation can be delivered using either an
open loop system or a closed loop system with feedback.

K. Meghpara, J. Vaghashiya, N.H. Shah, D.
Desai, W. Phuapradit, H.K. Sandhu, S.R.K
Vaka, N.B. Shelke, and A. Chatterji; Kashiv
Biosciences LLC, NJ; US Patent # 10,857,098;
December 8, 2020.

Methods and Devices for Delivery
of Pharmaceutical Agents Within
Orifices of the Body; N. Barak;

RDD Pharma Ltd, Tel Aviv, Israel; US
Patent # 10,821,274; November 3, 2020.
Oral dosage forms may suffer from several drawbacks such as
poor bioavailability, too slow or too fast drug delivery, first-pass
metabolism, etc. Orifices such as the nose, ear, rectum, and vagina
offer the possibility of delivering medicines. Different dosage forms
such as suppositories, tampons, vaginal implants, sprays, drops etc.
can be used. The patent claims a drug delivery device comprising
an active agent and a carrier, wherein the carrier has a melting point
of 23°C to 37.5°C and the carrier may be PEG. The device has a shell
elastically stressed by the pharmaceutical composition and the
shell is configured for the respective orifice of the body.

K.H. Rosenluth, S.L. Delp, J. Paderi,
V. Rajasekhar, and T. Altman;
Cala Health, Inc., CA; US Patent #
10,850,090; December 1, 2020.

Ophthalmic Drug Delivery;

B.L. Ballou, Jr., M. Packer, R.J. Mumper,
and T. Ianchulev; Evenovia, Inc., NY; US
Patent # 10,839,960; November 17, 2020.
Despite traditional eye drops being convenient and simple
to use, they are not very efficient. Only a small amount of the
dose is effectively delivered and retained to its intended target,
most is lost due to clearance mechanisms. The present patent
includes and provides a method of delivering a medicament to
an eye. The method includes: (a) providing droplets containing
the medicament with a specified average size and average initial
ejecting velocity; and (b) delivering the medicament to the eye,
where the droplets deliver a percentage of the ejected mass
of the droplets to the eye. Percentage can vary between 80 to
100% of the ejected mass.

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APR March 2021

Table of Contents for the Digital Edition of APR March 2021

Editor's Message
Editorial Advisory Board
CN Perspectives
Social Media Connections
Manufacturing
Microbiology
Equipmet Focus
Microbiology
Vendor Viewpoint
QC Corner with Millipore Sigma
Manufacturing
Biopharmaceutical Development
Biopharmaceutical Development
Manufacturing
Microbiology
Manufacturing
Separation and Purification
P.I.N. Points
Advertiser's Index
APR March 2021 - Cover1
APR March 2021 - Cover2
APR March 2021 - 1
APR March 2021 - 2
APR March 2021 - 3
APR March 2021 - 4
APR March 2021 - 5
APR March 2021 - Editor's Message
APR March 2021 - 7
APR March 2021 - Editorial Advisory Board
APR March 2021 - 9
APR March 2021 - CN Perspectives
APR March 2021 - Social Media Connections
APR March 2021 - Manufacturing
APR March 2021 - 13
APR March 2021 - 14
APR March 2021 - 15
APR March 2021 - 16
APR March 2021 - 17
APR March 2021 - 18
APR March 2021 - 19
APR March 2021 - Microbiology
APR March 2021 - 21
APR March 2021 - 22
APR March 2021 - 23
APR March 2021 - 24
APR March 2021 - Equipmet Focus
APR March 2021 - Microbiology
APR March 2021 - 27
APR March 2021 - 28
APR March 2021 - 29
APR March 2021 - 30
APR March 2021 - 31
APR March 2021 - 32
APR March 2021 - Vendor Viewpoint
APR March 2021 - 34
APR March 2021 - 35
APR March 2021 - QC Corner with Millipore Sigma
APR March 2021 - 37
APR March 2021 - Manufacturing
APR March 2021 - 39
APR March 2021 - 40
APR March 2021 - 41
APR March 2021 - Biopharmaceutical Development
APR March 2021 - 43
APR March 2021 - 44
APR March 2021 - Biopharmaceutical Development
APR March 2021 - 46
APR March 2021 - 47
APR March 2021 - Manufacturing
APR March 2021 - 49
APR March 2021 - 50
APR March 2021 - 51
APR March 2021 - 52
APR March 2021 - 53
APR March 2021 - 54
APR March 2021 - 55
APR March 2021 - Microbiology
APR March 2021 - 57
APR March 2021 - 58
APR March 2021 - 59
APR March 2021 - Manufacturing
APR March 2021 - 61
APR March 2021 - 62
APR March 2021 - 63
APR March 2021 - 64
APR March 2021 - Separation and Purification
APR March 2021 - 66
APR March 2021 - 67
APR March 2021 - 68
APR March 2021 - 69
APR March 2021 - P.I.N. Points
APR March 2021 - 71
APR March 2021 - Advertiser's Index
APR March 2021 - Cover3
APR March 2021 - Cover4
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