Engineering the immune response for therapeutic success I n the first of the articles included in this eBook, Carl June describes the development of CAR T cells as "a long and winding road." This and other selected articles indicate why this is so: the immune system is complex and no one cell type works in isolation. Thus, to be successful in the immune suppressive solid tumour microenvironment CAR T-cells need to be armed with a diverse set of capabilities. Horizon Discovery has gene modulation capabilities that can help to achieve this. 3| GENengnews.comhttp://www.GENengnews.com