Hospital Pharmacy - October 2019 - 312
312
Hospital Pharmacy 54(5)
Table 1. Patient Characteristics.
Overall (N = 94)
Median age, y
Female, n (%)
Females of childbearing potential, n (%)
Race/ethnicity, n (%)
White/Caucasian
Black/African American
Other
Medication, n (%)
Ambrisentan
Bosentan
Macitentan
Riociguat
Pulmonary unit, n (%)
Initiation of therapy inpatient, n (%)
Preinformatics (n = 50)
Postinformatics (n = 44)
54.9
65 (69.1)
19 (29.2)
54
33 (66)
11 (33.3)
55.9
32 (72.7)
8 (25.0)
55 (57.9)
33 (34.7)
7 (7.4)
31 (62)
16 (32)
3 (6)
24 (55.8)
17 (39.6)
2 (4.6)
41 (43.6)
17 (18.1)
21 (22.3)
15 (16)
51 (54.3)
15 (16)
24 (48)
12 (24)
7 (14)
7 (14)
28 (57.1)
8 (16)
17 (38.6)
5 (11.4)
14 (31.8)
8 (18.2)
23 (51.1)
7 (15.9)
Figure 3. REMS compliance endpoints.
Note. REMS = risk evaluation and mitigation strategies; LFT = liver function tests.
Discussion
The goal of the informatics changes implemented at this
institution was to increase compliance to the specified REMS
requirements, improving overall patient safety. By updating
the ordering panel and including required questions, compliance to pregnancy tests being completed in FCBP and LFTs
performed in patients on bosentan increased to 100%.
Therefore, it is clear that this newly initiated informatics
update substantially improved overall compliance to the
REMS programs for the ERAs and riociguat.
Prior to the informatics update in March 2016, pharmacists were not prompted to create an iVent within the patient
chart to verify and document REMS requirements were met
by the ordering provider. With the informatics update,
pharmacists are alerted to complete the verification step,
ensuring all REMS requirements are met prior to verifying
the medication. This, along with other ordering changes, has
improved overall compliance with both pregnancy tests and
LFTs being performed within 30 days of medication
initiation.
CDS tools have been developed for other drugs that have
REMS at our institution, including clozapine, olanzapine
pamoate, vigabatrin, and buprenorphine/naloxone. However,
this is the first retrospective analysis of these tools' ability to
improve compliance. Due to the positive results, the implementation of new tools and optimization of current tools are being
assessed. In addition, retrospective analyses will be performed
on the other medications as more data becomes available and
potential surveys for feedback on the tools may be collected.
Hospital Pharmacy - October 2019
Table of Contents for the Digital Edition of Hospital Pharmacy - October 2019
TOC/Verso
Disrespectful Behavior in Health System Pharmacy Practice: Consequences and Next Steps
The Orphan Drug Act: An Appropriate Approval Pathway for Treatments of Rare Diseases?
Significant Published Articles for Pharmacy Nutrition Support Practice in 2018
Impact of Delayed Oral Vancomycin for Severe Clostridium difficile Infection
Evaluation of a Hospital Pharmacist Annual Competency Program
A Retrospective Analysis of Adherence to Risk Evaluation and Mitigation Strategies Requirements for Pulmonary Arterial Hypertension Drugs
Impact of an Advanced Pharmacy Practice Experience Student-Run “Meds 2 Beds” and Discharge Counseling Program on Quality of Care
A Retrospective Surveillance of the Antibiotics Prophylactic Use of Surgical Procedures in Private Hospitals in Indonesia
Stability and Compatibility of Diphenhydramine Hydrochloride in Intravenous Admixtures: A New Look at an Old Drug
The Impact of an Automated Dispensing System for Supplying Narcotics in a Surgical Unit: The Experience of the National Cancer Institute Foundation of Milan
Hospital Pharmacy - October 2019 - Cover1
Hospital Pharmacy - October 2019 - Cover2
Hospital Pharmacy - October 2019 - 277
Hospital Pharmacy - October 2019 - TOC/Verso
Hospital Pharmacy - October 2019 - 279
Hospital Pharmacy - October 2019 - Disrespectful Behavior in Health System Pharmacy Practice: Consequences and Next Steps
Hospital Pharmacy - October 2019 - 281
Hospital Pharmacy - October 2019 - 282
Hospital Pharmacy - October 2019 - The Orphan Drug Act: An Appropriate Approval Pathway for Treatments of Rare Diseases?
Hospital Pharmacy - October 2019 - 284
Hospital Pharmacy - October 2019 - Significant Published Articles for Pharmacy Nutrition Support Practice in 2018
Hospital Pharmacy - October 2019 - 286
Hospital Pharmacy - October 2019 - 287
Hospital Pharmacy - October 2019 - 288
Hospital Pharmacy - October 2019 - 289
Hospital Pharmacy - October 2019 - 290
Hospital Pharmacy - October 2019 - 291
Hospital Pharmacy - October 2019 - 292
Hospital Pharmacy - October 2019 - 293
Hospital Pharmacy - October 2019 - Impact of Delayed Oral Vancomycin for Severe Clostridium difficile Infection
Hospital Pharmacy - October 2019 - 295
Hospital Pharmacy - October 2019 - 296
Hospital Pharmacy - October 2019 - 297
Hospital Pharmacy - October 2019 - 298
Hospital Pharmacy - October 2019 - 299
Hospital Pharmacy - October 2019 - Evaluation of a Hospital Pharmacist Annual Competency Program
Hospital Pharmacy - October 2019 - 301
Hospital Pharmacy - October 2019 - 302
Hospital Pharmacy - October 2019 - 303
Hospital Pharmacy - October 2019 - 304
Hospital Pharmacy - October 2019 - 305
Hospital Pharmacy - October 2019 - 306
Hospital Pharmacy - October 2019 - 307
Hospital Pharmacy - October 2019 - 308
Hospital Pharmacy - October 2019 - A Retrospective Analysis of Adherence to Risk Evaluation and Mitigation Strategies Requirements for Pulmonary Arterial Hypertension Drugs
Hospital Pharmacy - October 2019 - 310
Hospital Pharmacy - October 2019 - 311
Hospital Pharmacy - October 2019 - 312
Hospital Pharmacy - October 2019 - 313
Hospital Pharmacy - October 2019 - Impact of an Advanced Pharmacy Practice Experience Student-Run “Meds 2 Beds” and Discharge Counseling Program on Quality of Care
Hospital Pharmacy - October 2019 - 315
Hospital Pharmacy - October 2019 - 316
Hospital Pharmacy - October 2019 - 317
Hospital Pharmacy - October 2019 - 318
Hospital Pharmacy - October 2019 - 319
Hospital Pharmacy - October 2019 - 320
Hospital Pharmacy - October 2019 - 321
Hospital Pharmacy - October 2019 - 322
Hospital Pharmacy - October 2019 - A Retrospective Surveillance of the Antibiotics Prophylactic Use of Surgical Procedures in Private Hospitals in Indonesia
Hospital Pharmacy - October 2019 - 324
Hospital Pharmacy - October 2019 - 325
Hospital Pharmacy - October 2019 - 326
Hospital Pharmacy - October 2019 - 327
Hospital Pharmacy - October 2019 - 328
Hospital Pharmacy - October 2019 - 329
Hospital Pharmacy - October 2019 - Stability and Compatibility of Diphenhydramine Hydrochloride in Intravenous Admixtures: A New Look at an Old Drug
Hospital Pharmacy - October 2019 - 331
Hospital Pharmacy - October 2019 - 332
Hospital Pharmacy - October 2019 - 333
Hospital Pharmacy - October 2019 - 334
Hospital Pharmacy - October 2019 - The Impact of an Automated Dispensing System for Supplying Narcotics in a Surgical Unit: The Experience of the National Cancer Institute Foundation of Milan
Hospital Pharmacy - October 2019 - 336
Hospital Pharmacy - October 2019 - 337
Hospital Pharmacy - October 2019 - 338
Hospital Pharmacy - October 2019 - 339
Hospital Pharmacy - October 2019 - 340
Hospital Pharmacy - October 2019 - 341
Hospital Pharmacy - October 2019 - 342
Hospital Pharmacy - October 2019 - 343
Hospital Pharmacy - October 2019 - 344
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