WSO - June 2023 - 549

Ball et al.
549
Figure 3. Unadjusted meta-analysis of neuroimaging features associated with cognitive outcome.
Studies which report either PSD or PSCI are included. OR: odds ratio; CI: Confidence Interval; WMH: White Matter Hyperintensities; cSVD:
cerebral small vessel disease; Isch: ischemic; ICH: Intracerebral Hemorrhage.
Sensitivity analysis
After controlling for pre-stroke cognitive impairment, we
also found a significant association between presence of
lacunes and PSCI/PSD (two studies, N = 244, ORu = 1.88,
95% CI = 1.06-3.35, I2 = 0%, p = 0.03)18,31. Results from the
sensitivity analyses are presented in Supplement 15.
Risk of bias
We rated no studies with high overall risk of bias (Figure 5).
Issues with external validity were common due to studies
including only specific stroke types (e.g. lacunar stroke,
middle cerebral artery lesion only) and excluding more
severe strokes. The majority of studies did not clearly report
the reasons for loss to follow-up.
Discussion
Key findings
This systematic review included 27 cohorts of patients with
stroke (N = 13,114). Features of cSVD, visible on acute
stroke MRI, were associated with PSCI/PSD. The presence
of cerebral atrophy, presence and severity of WMH, presence
of CMB, and total cSVD score were associated with
increased risk of either PSCI and/or PSD. More severe WMH
(adjusted), worse cSVD (unadjusted), presence of cerebral
atrophy (unadjusted), and presence of CMB (adjusted) were
associated with PSCI/PSD in meta-analyses. We did not find
associations between other features and PSCI/PSD or there
was insufficient evidence to draw a conclusion. Heterogeneity
between studies limited the potential to pool data.
International Journal of Stroke, 18(5)

WSO - June 2023

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WSO - June 2023 - Cover1
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WSO - June 2023 - 491
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WSO - June 2023 - Cover3
WSO - June 2023 - Cover4
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