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International Journal of Stroke 19(4)
Table 2. Critical appraisal summary of the included reviews.
Study
Bagheri et al.11
Huang et al.6
Oesch et al.2
Torres-Aguila et al.12
MacDonald et al.3
Zhang et al.4
Mehta et al.5
C1
N
U
U
U
Y
U
Y
C2
Y
Y
Y
U
Y
Y
Y
C3
Y
Y
U
N
Y
Y
U
C4
Y
U
N
N
Y
U
Y
C5
Y
Y
N
N
Y
Y
Y
C6
U
Y
N
N
Y
Y
Y
C7
Y
Y
U
N
Y
Y
Y
C8
U
Y
U
U
Y
Y
Y
C9
Y
Y
U
N
N
Y
Y
C10
U
U
U
U
U
U
U
C11
Y
Y
Y
U
Y
Y
Y
N = no; Y = yes; U = unclear; C1. Is the review question explicitly stated? C2. Were the inclusion criteria appropriate for the review question? C3.
Was the search strategy appropriate? C4. Were the sources and resources used to search for studies adequate? C5. Were the criteria for appraising
studies appropriate? C6. Was critical appraisal conducted by two or more reviewers independently? C7. Were there methods to minimize errors
in data extraction? C8. Were the methods used to combine studies appropriate? C9. Was the likelihood of publication bias assessed? C10. Were
recommendations for policy and/or practice supported by the reported data? C11. Were the specific directives for new research appropriate?
Table 3. Summary of main results (for each outcome measure categorized by body weight).
Systematic review
All-cause mortality
Bagheri et al.11
Huang et al.6
Oesch et al.2
Number of relevant
studies (number of
participants)
8 (95,651)
14 (102,226)
10 (162,921)
Torres-Aguila et al.12 2 (1961)
Zhang et al.4
Mehta et al.5
2 (NR)
Underweight 5 (1948)
Overweight 6 (42,814)
Obese 6 (6052)
Functional recovery
Oesch et al.2
9 (92,718)
Torres-Aguila et al.12 2 (1961)
MacDonald et al.3
Underweight 4 (1987);
Overweight N/A;
Obese 7 (3070)
Zhang et al.4
Underweight 4 (NR);
overweight 6 (NR);
obese 6 (NR)
Mehta et al.5
Overweight 2 (795)
Obese 2 (627)
Heterogeneity
High
High
NR
NR
Low
High
High
Low
NR
NR
NR
Low
Moderate
Underweight
(BMI < 18.5 kg/m2)
HR < 1.0
RR = 1.54
No HR reported
(increased mortality)
No HR reported
(no association)
uHR = 2.24
aHR = 1.65
Overweight
(BMI = 25-29.9 kg/m2) Obese (BMI > 30 kg/m2)
HR > 1.0
RR = 0.83
No HR reported
(decreased mortality)
No HR reported
(no association)
uHR = 0.83
aHR = 0.80
HR > 1.0
RR = 0.83
No HR reported
(decreased mortality)
No HR reported
(no association)
uHR = 0.83
aHR = 0.80
No OR reported
(decreased functional
recovery)
No OR reported
(no association)
No OR reported
(decreased functional
recovery)
uOR = 1.63
aOR = 2.21
No OR reported
(increased functional
recovery)
No OR reported
(no association)
No OR reported
(inconclusive findings)
uOR = 0.94
MD = 0.50
No significant
association
No OR reported
(increased functional
recovery)
No OR reported
(no association)
No OR reported
(inconclusive findings)
uOR = 0.93
MD = 2.26
No significant association
BMI: body mass index; HR: hazard ratio; RR: relative risk; NR: not reported; uHR: unadjusted hazard ratio; aHR: adjusted hazard ratio; OR: odds
ratio; N/A: not applicable; uOR: unadjusted odds ratio; aOR: adjusted odds ratio; MD: mean difference.
International Journal of Stroke, 19(4)
WSO - April 2024

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