1 IMPROVED HEALING The rich concentration of growth factors released from the activated platelets contained in PRF over 5-7 days is important to the overall healing of a surgical site. These growth factors are crucial in signaling cellular differentiation and for new vascular growth in the site. Because of the increase in growth factors, sites treated with PRF have shown to exhibit faster soft-tissue closure and faster bone remodeling.1 2 INFECTION PREVENTION PRF has an immunologic effect on grafted areas, demonstrably lowering the incidence of postoperative infections because of the high concentration of leukocytes. Numerous studies have noted that PRF releases growth factors over a long period of time, particularly in the critical time between soft tissue healing and early bone growth.2 64 JULY 2022 // dentaltown.com 3 VERSATILITY Fig. 3: A plasma-rich fibrin (PRF) membrane layer after being pressed thin in the expression box.http://www.dentaltown.com