Meat+Poultry - April 2017 - 29

SALMONELLA CONTROL STARTS ON DAY 1

Advertorial

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Controlling 6DOPRQHOOD in live poultry production can be
a challenge. 6DOPRQHOOD is a commensal organism in the
gastrointestinal tract, and the birds themselves can be latent
carriers, shedding the disease when they are stressed. That's
why a 6DOPRQHOOD vaccination program that includes both
live and inactivated vaccines can be effective in reducing
6DOPRQHOOD Enteritidis (SE) infections of laying hens and
broilers to help protect the food chain.
"Studies1,2 show that a live vaccine provides early intestinal
protection," says Sara Steinlage, D.V.M., Elanco® poultry
technical advisor. "When you combine that with an
inactivated 6DOPRQHOOD vaccine, you can provide long-term
SURWHFWLRQDJDLQVWVSHFL¿FVHURYDUVDQGHQVXUHWKHGHSRVLW
of yolk antibody in the egg."
Intestinal Lining of Day-Old Bird

Before coarse spray with live
Salmonella vaccination

After coarse spray with live
Salmonella vaccination

LIVE VACCINES
In a controlled study,2 AviPro® Megan® Vac 1 research has
VKRZQVLJQL¿FDQWUHGXFWLRQVRI6Typhimurium (ST), 6
Heidelberg (SH) and SE infections in chickens. One-day-old
leghorn chicks were vaccinated with AviPro Megan Vac 1,
revaccinated through drinking water at two weeks of age and
then challenged with ST, SE and SH wild-type strains at six
weeks of age.
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reduced 6DOPRQHOOD colonization post-challenge when
compared to non-vaccinated birds.1 Research has shown

Percent wild-type 6DOPRQHOOD positive samples

Efﬁcacy Trial Results1
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that in addition to providing excellent protection against
theimportant serogroups B and D (SE, ST and SH), AviPro
0HJDQ9DFLQGXFHVVLJQL¿FDQWFURVVSURWHFWLRQDJDLQVW
6DOPRQHOOD strains belonging to serogroups C and E.3

INACTIVATED VACCINES
In a controlled study,4 AviPro 109 SE4, an inactivated
6 Enteritidis bacterin vaccine, effectively reduced 6DOPRQHOOD
infections in laying hens. Pullet hens were vaccinated at
12 and 16 weeks of age and then challenged with wild-type
infections of 6 Enteritidis phage-type 4, 6 Typhimurium
and 6 Heidelberg.
Post-challenge, birds treated with AviPro 109 SE4 showed
VLJQL¿FDQWO\UHGXFHG6DOPRQHOOD colonization in internal
organs, including liver and spleen and the ovaries and
oviducts, as compared to non-vaccinated hens.

WORKING TOGETHER
"When these vaccination methods are used, they parallel
the natural infection path of 6DOPRQHOOD," says Steinlage.
"This triggers the local, humoral and cell-mediated immune
responses that are unique to live 6DOPRQHOOD vaccines, which
means infections and shedding are reduced when birds
HQFRXQWHUD¿HOGLQIHFWLRQRIZLOGW\SH6DOPRQHOOD."
Mitigating risk from egg to end-consumer starts by prioritizing
bird health and food chain safety with a consistent,
comprehensive 6DOPRQHOOD control program.

TAKE CONTROL
While a comprehensive 6DOPRQHOOD control program is
necessary to disrupt the transmission of 6DOPRQHOOD,
vaccination alone cannot be relied upon to prevent
6DOPRQHOOD infections.
A comprehensive 6DOPRQHOOD control program should
include:
* Optimizing gut health
* Strong biosecurity measures
* Environmental monitoring
* Litter management
* Pest and rodent control
* Water and feed management
To learn more about how Elanco can help you manage
6DOPRQHOOD, visit (ODQFRXV0HJDQ or contact your local
Elanco sales representative.

100

The label contains complete use information, including
cautions and warnings. Always read, understand and follow
label and use directions.

AviPro Megan Vac1

Control

Elanco Animal Health. Data on ﬁle.
Elanco Animal Health. Data on ﬁle.
Hassan and Curtiss. 1994. "Development and evaluation of an experimental vaccination program using a live avirulent
Salmonella typhimurium strain to protect immunized chickens against challenge with homologous and heterologous
Salmonella serotypes." Infect. Immun. 62:5519-5527.
4
Elanco Animal Health. Data on ﬁle.
2

Percent wild-type SH, SE or ST positive samples
5 to 7 days post-challenge.
*Signiﬁcantly different by (χ)2 test; P<0.05.

AviPro, Megan, Elanco, and the diagonal bar logo are trademarks of Eli Lilly and Company or its aﬃliates.
© 2017 Eli Lilly and Company or its aﬃliates.
vacc 5949-1 | USPBUAVP00054

Meat+Poultry - April 2017

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