WSO December 2023 – Issue 3 - 1219

1181010
WSO
International Journal of StrokeMoutzouri et al.
Research
Association of statin use and lipid
levels with cerebral microbleeds and
intracranial hemorrhage in patients
with atrial fibrillation: A prospective
cohort study
International Journal of Stroke
2023, Vol. 18(10) 1219 -1227
© 2023 World Stroke Organization
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DOI: 10.1177/17474930231181010
journals.sagepub.com/home/wso
https://doi.org/10.1177/17474930231181010
Elisavet Moutzouri1,2,3 , Matthias Glutz1, Nazanin Abolhassani1,4,
Martin Feller1 , Luise Adam1, Baris Gencer1,5, Cinzia
Del Giovane1, Sylvain Bétrisey1, Rebecca E Paladini6, Elisa
Hennings6,7 , Stefanie Aeschbacher6,7, Jürg H Beer8, Giorgio
Moschovitis9, David Seiffge10, Gian Marco De Marchis11, Michael
Coslovsky6,12, Tobias Reichlin13, Giulio Conte14, Tim Sinnecker11,
Matthias Schwenkglenks15,16, Leo H Bonati11, Peter Kastner17,
Drahomir Aujesky1,2, Michael Kühne6,7, Stefan Osswald6,7, Urs
Fischer10,11 , David Conen13,18 and Nicolas Rodondi1,2; on behalf
of the Swiss-AF Investigators
Abstract
Background: An increased risk of intracranial hemorrhage (ICH) associated with statins has been reported, but data on
the relationship between statin use and cerebral microbleeds (CMBs) in patients with atrial fibrillation (AF), a population
at high bleeding and cardiovascular risk, are lacking.
Aims: To explore the association between statin use and blood lipid levels with the prevalence and progression of
CMBs in patients with AF with a particular focus on anticoagulated patients.
Methods: Data of Swiss-AF, a prospective cohort of patients with established AF, were analyzed. Statin use was assessed
during baseline and throughout follow-up. Lipid values were measured at baseline. CMBs were assessed using magnetic
1Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland
2Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
3Department of Hematology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
4Department of Epidemiology and Health Systems, Center for Primary Care and Public Health, (Unisanté), University of Lausanne, Lausanne, Switzerland
5Department of Cardiology, HUG, University Hospital Geneva, Geneva, Switzerland
6Cardiovascular Research Institute Basel, Basel University Hospital, University of Basel, Basel, Switzerland
7Cardiology Division, Department of Medicine, Basel University Hospital, University of Basel, Basel, Switzerland
8Department of Medicine, Cantonal Hospital of Baden and Center for Molecular Cardiology, University Hospital of Zurich, Zurich, Switzerland
9Cardiology Division, Regional Hospital of Lugano, Ente Ospedaliero Cantonale, Lugano, Switzerland
10Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
11Department of Neurology and Stroke Center, Basel University Hospital, University of Basel, Basel, Switzerland
12Department Clinical Research, Basel University Hospital, University of Basel, Basel, Switzerland
13Division of Cardiology, Department of Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
14Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale, Lugano, Switzerland
15Epidemiology, Biostatistics and Prevention Institute (EBPI), University of Zurich, Zurich, Switzerland
16Institute of Pharmaceutical Medicine (ECPM), University of Basel, Basel, Switzerland
17Roche Diagnostics GmbH, Penzberg, Germany
18Population Health Research Institute, McMaster University, Hamilton, ON, Canada
Corresponding author:
Elisavet Moutzouri, Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Bern 3010, Switzerland.
Email: elisavet.moutzouri@extern.insel.ch
International Journal of Stroke, 18(10)
https://www.doi.org/10.1177/17474930231181010 http://www.sagepub.com/journals-permissions http://journals.sagepub.com/home/wso
WSO December 2023 – Issue 3

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