WSO December 2023 – Issue 3 - 1245

Cappellari et al.
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in five patients develop HT or early CED, but rate of symptomatic
HT and/or CED is very low. However, even if
asymptomatic at 24 h, PH could delay the introduction of
secondary prevention antithrombotic therapy and expose
the patients to a higher risk of early stroke recurrence, while
CED could increase its extension and cause a neurological
deterioration beyond 24 h. Intra- and post-operative management
during anesthesia should assume an increasingly
relevant and specialized role, both to gain new insights into
the complex mechanisms underlying reperfusion injury and
to modify the modifiable risk factors associated with HT
and early CED, such as
maintaining good collateral
circulation.
Conclusion
Our study reported that higher NIHSS, lower ASPECTS,
and longer onset-to-groin time were predictors for both HT
and early CED in stroke patients after first-pass complete
recanalization during MT. General anesthesia and good
collaterals were inversely associated with HT and CED,
respectively. Longer procedure time was predictor of early
CED.
Acknowledgements
We thank all persons who participated in IRETAS.
Author contributions
Manuel Cappellari: design and conceptualization of the study,
acquisition of data, analysis and interpretation of the data, and
drafting the manuscript for intellectual content. All authors: acquisition
of data and revising the manuscript for intellectual content.
Declaration of conflicting interests
The author(s) declared the following potential conflicts of interest
with respect to the research, authorship, and/or publication of this
article: Manuel Cappellari received consultancy or advisory board
fees or speaker's honoraria from Boehringer Ingelheim, Pfizer/
Bristol Meyer Squibb, and Daiichi Sankyo. Andrea Zini received
consulting fees from Boehringer-Ingelheim consulting fees from
Boehringer-Ingelheim, Alexion and CLS Behring. All other
authors report no conflicts of interest. The other authors report no
conflicts.
Funding
The author(s) disclosed receipt of the following financial support
for the research, authorship, and/or publication of this article:
" The project
''Registro Nazionale Trattamento Ictus Acuto''
(RFPS-2006-1-336562) was funded by grants from the Italian
Ministry of Health within the framework of 2006 Finalized
Research Programmes (D.Lgs.n.502/1992). The present study
received no funding.
ORCID iDs
Manuel Cappellari
https://orcid.org/0000-0002-3534-3201
Ilaria Casetta
Andrea Zini
Marta Iacobucci
Ettore Nicolini
Francesco Capasso
Guido Bigliardi
https://orcid.org/0000-0003-4099-8875
https://orcid.org/0000-0003-1087-6092
https://orcid.org/0000-0001-5312-7206
https://orcid.org/0000-0003-1486-4507
https://orcid.org/0000-0002-3911-3278
https://orcid.org/0000-0002-8481-6327
Supplemental material
Supplemental material for this article is available online.
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https://www.orcid.org/0000-0003-4099-8875 https://www.orcid.org/0000-0003-1087-6092 https://www.orcid.org/0000-0001-5312-7206 https://www.orcid.org/0000-0003-1486-4507 https://www.orcid.org/0000-0002-3911-3278 https://www.orcid.org/0000-0002-8481-6327 https://www.orcid.org/0000-0002-3534-3201
WSO December 2023 – Issue 3

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