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International Journal of Stroke 19(3)
diagnostic algorithm of ESUS. Dedicated MRI sequences
capable of capturing high-risk functional features beyond
anatomical imaging may further boost the clinical applicability
of this technique in the stroke setting. Comparative
studies against other imaging modalities are needed to
demonstrate the cost-effectiveness of MRI in ESUS
investigation.
Acknowledgements
The authors acknowledge the
Foundation
Centre
for
support of the
Research
Excellence Award
British Heart
III
(RE/18/5/34216). SEW is supported by the British Heart
Foundation (FS/20/26/34952). The authors acknowledge the support
of the British Heart Foundation (PG/19/44/34368).
Declaration of conflicting interests
The author(s) declared no potential conflicts of interest with
respect to the research, authorship, and/or publication of this
article.
Funding
The author(s) received no financial support for the research,
authorship, and/or publication of this article.
ORCID iDs
Natallia Khenkina
Dimitrios Sagris
Hui-Sheng Chen
Patrik Michel
https://orcid.org/0000-0002-0798-639X
https://orcid.org/0000-0001-6657-5665
https://orcid.org/0000-0002-7486-1992
https://orcid.org/0000-0003-4954-7579
Supplemental material
Supplemental material for this article is available online.
References
1. Ntaios G and Hart RG. Embolic stroke. Circulation 2017;
136: 2403-2405.
2. Ntaios G, Papavasileiou V, Milionis H, et al. Embolic strokes
of undetermined source in the Athens stroke registry: a
descriptive analysis. Stroke 2015; 46: 176-181.
3. Hart RG, Diener HC, Coutts SB, et al. Embolic strokes of
undetermined source: the case for a new clinical construct.
Lancet Neurol 2014; 13: 429-438.
4. Hart RG, Catanese L, Perera KS, Ntaios G and Connolly SJ.
Embolic stroke of undetermined source: a systematic review
and clinical update. Stroke 2017; 48: 867-872.
5. Diener H-C, Sacco RL, Easton JD, et al. Dabigatran for prevention
of stroke after embolic stroke of undetermined source.
N Engl J Med 2019; 380: 1906-1917.
6. Tandon K, Tirschwell D, Longstreth WT, et al. Embolic stroke
of undetermined source correlates to atrial fibrosis without
atrial fibrillation. Neurology 2019; 93: e381-e387.
7. Kühnlein P, Mahnkopf C, Majersik JJ, et al. Atrial fibrosis in
embolic stroke of undetermined source: a multicenter study.
Eur J Neurol 2021; 28: 3634-3639.
International Journal of Stroke, 19(3)
8. Fonseca AC, Alves P, Inácio N, et al. Patients with undetermined
stroke have increased atrial fibrosis: a cardiac magnetic
resonance imaging study. Stroke 2018; 49: 734-737.
9. Kroman A, Mahnkopf C, Kühnlein P, et al. Abstract: 11540
embolic stroke of unknown source is associated with atrial
fibrosis similar to atrial fibrillation. Circulation 2019; 140:
A11540.
10. Daccarett M, Badger TJ, Akoum N, et al. Association of left
atrial fibrosis detected by delayed-enhancement magnetic
resonance imaging and the risk of stroke in patients with atrial
fibrillation. J Am Coll Cardiol 2011; 57: 831-838.
11. Akoum N, Fernandez G, Wilson B, Mcgann C, Kholmovski
E and Marrouche N. Association of atrial fibrosis quantified
using LGE-MRI with atrial appendage thrombus and spontaneous
contrast on transesophageal echocardiography in
patients with atrial fibrillation. J Cardiovasc Electrophysiol
2013; 24: 1104-1109.
12. Hong YJ, Hur J, Kim YJ, et al. The usefulness of delayed contrast-enhanced
cardiovascular magnetic resonance imaging in
differentiating cardiac tumors from thrombi in stroke patients.
Int J Cardiovasc Imaging 2011; 27: 89-95.
13. Velangi PS, Choo C, Chen KA, et al. Long-term embolic
outcomes after detection of left ventricular thrombus by late
gadolinium enhancement cardiovascular magnetic resonance
imaging: a matched cohort study. Circ Cardiovasc Imaging
2019; 12: e009723.
14. Haeusler KG, Wollboldt C, Bentheim LZ, et al. Feasibility
and diagnostic value of cardiovascular magnetic resonance
imaging after acute ischemic stroke of undetermined origin.
Stroke 2017; 48: 1241-1247.
15. Merkler AE, Sigurdsson S, Eiriksdottir G, et al. Association
between unrecognized myocardial infarction and cerebral
infarction on magnetic resonance imaging. JAMA Neurol
2019; 76: 956-961.
16. Toupin S, Pezel T, Sanguineti F, et al. Additional prognostic
value of stress cardiovascular magnetic resonance for cardiovascular
risk stratification after a cryptogenic ischemic stroke.
Front Cardiovasc Med 2022; 9: 956950.
17. Fonseca AC, Marto JP, Pimenta D, et al. Undetermined stroke
genesis and hidden cardiomyopathies determined by cardiac
magnetic resonance. Neurology 2020; 94: e107-e113.
18. Pöyhönen P, Kuusisto J, Järvinen V, et al. Left ventricular noncompaction
as a potential source for cryptogenic ischemic
stroke in the young: a case-control study. PLoS ONE 2020;
15: e0237228.
19. Singh N, Moody AR, Panzov V and Gladstone DJ. Carotid
intraplaque hemorrhage in patients with embolic stroke of
undetermined source. J Stroke Cerebrovasc Dis 2018; 27:
1956-1959.
20. Hyafil F, Schindler A, Sepp D, et al. High-risk plaque features
can be detected in non-stenotic carotid plaques of patients
with ischaemic stroke classified as cryptogenic using combined
18 F-FDG PET/MR imaging. Eur J Nucl Med Mol
Imaging 2016; 43: 270-279.
21. Kopczak A, Schindler A, Bayer-Karpinska A, et al.
Complicated carotid artery plaques as a cause of cryptogenic
stroke. J Am Coll Cardiol 2020; 76: 2212-2222.
22. Freilinger TM, Schindler A, Schmidt C, et al. Prevalence of
nonstenosing, complicated atherosclerotic plaques in cryptogenic
stroke. JACC Cardiovasc Imaging 2012; 5: 397-405.
https://www.orcid.org/0000-0002-0798-639X https://www.orcid.org/0000-0001-6657-5665 https://www.orcid.org/0000-0002-7486-1992 https://www.orcid.org/0000-0003-4954-7579
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