Tumori Journal Abstract Book - October 2020 - 84

84
managing pandemic in very short time. In the oncology
department (hospitalization and DH) there have been effects
that have changed the working lifestyle of the health workers
(director, doctors, nurses, socio-health assistants and administrative staff within the department) therefore an attempt
was made to measure their nature and impact. The aspects
investigated were stress, anxiety, depression and insomnia.
Methods: The methods used are the naturalistic observation and the self-report questionnaires: the Dass-21 and the
index insomnia. The research was very well received by
the operators, eager both to make a contribution to the
research, and to know their psychological situation, specifically the emotional sphere.
Results: The questionnaires revealed a discomfort distributed
on all health workers, in particular: stress 65% (30% severe
and extremely severe, 25% moderate, 10% average); anxiety
45% (25% severe and extremely severe, 5% moderate, 15%
average); depression 40% (20% severe and extremely severe,
10% moderate, 10% medium); insomnia 30% (15% severe
and 15% moderate). We have chosen to report only the clinically significant and deserving percentages of a psychological
support intervention. The naturalistic observation confirmed
the results obtained in the self-assessment questionnaires: the
health staff in the oncology department experienced more
stressful situations, anxiety, depression and insomnia especially for those who work in close contact with patients and
therefore perceive greater vulnerability to contagion.
Nevertheless, the data that emerged disconfirm the expectations, it was in fact thought to record higher scores.
Conclusions: Covid-19 put a strain on the work organization
in the oncology department, changing the lifestyle of health
workers both in terms of coping and interpersonal interactions. Contrary to expectations, there was a good cognitive
and emotional management of the emergency, probably due
to precise precautions to be adopted (PPE, reduction of the
influx of users and social distancing), pre-existing exposure
to death and its processing, good resources personal and
social in the management of the covid-19 emergency. Cases
of stress, anxiety and depression will be monitored and taken
care of for a clinical psychological intervention.

D37
Swab negative NSCLC patients (pts)
with clinical and radiological
features suggestive for COVID-19: a
single center experience
Palesandro E.1, Bertaglia V.2, Bironzo P.2, Reale M.L.2, Leone G.2,
Tabbò F.2, Bungaro M.2, Audisio M.2, Mariniello A.2, Rapetti S.2, Di
Stefano R.F.2, Artusio E.2, Capelletto E.2, Sperone P.2, Caramello V.3,
Calandri M.4, Perboni A.5, Passiglia F.2, Novello S.2
1
Thoracic Oncology Unit. Department of Oncology, University of Turin,
San Luigi Gonzaga Hospital, Orbassano, Torino; 2Thoracic Oncology Unit.
Department of Oncology, University of Turin, San Luigi Gonzaga Hospital,
Orbassano, Torino; 3Emergency Medicine, San Luigi Gonzaga Hospital,
Orbassano, Torino; 4Radiology Unit, Department of Oncology, University of

Tumori Journal 106(2S)
Turin, San Luigi Gonzaga Hospital, Orbassano, Torino; 5Pulmonology Unit, S.
Luigi Gonzaga Hospital, Orbassano, Torino

Background: During COVID-19 pandemic, timely diagnosis of SARS-CoV-2 infection was crucial, especially in pts
with cancer. Real-time polymerase chain reaction (RT-PCR)
on nasopharyngeal swab (NPS) is hampered by ≈30% of
false negatives. Clinical and radiological features may identify potentially infected cases in presence of negative test.
Materials and methods: We retrospectively retrieved
records from 30 pts admitted to our Onco-Covid Unit.
Clinical (fever, cough, respiratory failure) and radiological
(ground glass opacities - GGO with or without lung consolidation) criteria were assessed. NPS RT-PCR was performed (VIASURE SARS COV-2 RT-PCR Detection Kit)
at admission and at 48 hours. Pts underwent laboratory and
radiological assessments (chest x-ray, bedside lung ultrasonography, thorax CT scan). Other sources of infection
were ruled out (blood cultures, pneumococcal/legionella
urinary antigen tests) as well as radiological differential
diagnoses (e.g. disease progression).
Results: From March 21st to May 9th 2020, 9 NPS negative
pts with both clinical and radiological features suggestive
for COVID-19 were identified. Mean age was 65.1 (3178), 4 were female, all with ECOG PS 1. 4 pts had COPD,
8 were stage IV. All pts were on active antitumor treatment. Most common symptoms were dyspnea (n 8), fever
(n 5), dry cough (n 3); radiological features include: GGOs
alone (n 6), consolidation (n 1), consolidation + GGOs (n
1). 3 pts had baseline lymphopenia, 7 high lactate dehydrogenase, 8 high C-reactive protein. All pts presented with
respiratory failure: PaO2/FiO2 ratio <200 (n 3), 200-300
(n 5), > 300 (n 1). All pts received antibiotics (azithromycin + ceftriaxone 3; piperacillin/tazobactam 6), glucocorticoids, O2-therapy: nasal cannula (n 3), Venturi mask (n
2), non-invasive ventilation (n 4). 4 pts died and 5 were
discharged from the hospital, 4 with the indication to
active antitumor treatment and 1 to best supportive care.
Conclusions: High suspicion index is necessary in NSCLC
pts with respiratory symptoms during COVID-19 pandemic
as NPS may not identify all infected pts and the number of
"gray cases" is expected to increase in Phase II. Clinical and
radiological findings correlation is pivotal in this subgroup.

D38
Management of NSCLC patients
during the COVID-19 pandemic:
results from an Italian Survey
Bertaglia V.1, Reale M.L.1, Passiglia F.1, Palesandro E.1, Bironzo P.1,
Olmetto E.1, Leone G.M.1, Tabbò F.1, Bungaro M.1, Audisio M.1,
Mariniello A.1, Rapetti S.2, Di Stefano R.F.3, Napoli V.M.4, Artusio E.5,
Capelletto E.5, De Filippis M.5, Jacobs F.5, Sperone P.5, Novello S.5
1
Department of Oncology, University of Turin, San Luigi Gonzaga Hospital,
Orbassano, Torino, Italy; 2Pneumologia, San Luigi Gonzaga Hospital,
Orbassano, Torino, Italy; 3 Department of Oncology, University of Turin, San

Tumori Journal Abstract Book - October 2020

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